全文获取类型
收费全文 | 36171篇 |
免费 | 4224篇 |
国内免费 | 2125篇 |
专业分类
电工技术 | 3115篇 |
技术理论 | 1篇 |
综合类 | 2925篇 |
化学工业 | 5142篇 |
金属工艺 | 2166篇 |
机械仪表 | 2711篇 |
建筑科学 | 2896篇 |
矿业工程 | 1304篇 |
能源动力 | 940篇 |
轻工业 | 3100篇 |
水利工程 | 849篇 |
石油天然气 | 1408篇 |
武器工业 | 433篇 |
无线电 | 4450篇 |
一般工业技术 | 3622篇 |
冶金工业 | 1345篇 |
原子能技术 | 494篇 |
自动化技术 | 5619篇 |
出版年
2024年 | 100篇 |
2023年 | 631篇 |
2022年 | 1376篇 |
2021年 | 1772篇 |
2020年 | 1445篇 |
2019年 | 1064篇 |
2018年 | 1252篇 |
2017年 | 1402篇 |
2016年 | 1299篇 |
2015年 | 2085篇 |
2014年 | 2465篇 |
2013年 | 2756篇 |
2012年 | 3114篇 |
2011年 | 3192篇 |
2010年 | 2804篇 |
2009年 | 2474篇 |
2008年 | 2352篇 |
2007年 | 2148篇 |
2006年 | 1948篇 |
2005年 | 1568篇 |
2004年 | 1138篇 |
2003年 | 743篇 |
2002年 | 634篇 |
2001年 | 544篇 |
2000年 | 472篇 |
1999年 | 362篇 |
1998年 | 261篇 |
1997年 | 203篇 |
1996年 | 204篇 |
1995年 | 151篇 |
1994年 | 116篇 |
1993年 | 99篇 |
1992年 | 85篇 |
1991年 | 58篇 |
1990年 | 45篇 |
1989年 | 49篇 |
1988年 | 22篇 |
1987年 | 15篇 |
1986年 | 4篇 |
1985年 | 9篇 |
1984年 | 7篇 |
1982年 | 4篇 |
1981年 | 7篇 |
1980年 | 17篇 |
1979年 | 3篇 |
1976年 | 4篇 |
1968年 | 1篇 |
1966年 | 1篇 |
1959年 | 5篇 |
1951年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Xiao-Mei Sha Li-Jun Zhang Wen-Mei Chen Guang-Yao Wang Jin-Lin Li Zi-Zi Hu Zong-Cai Tu 《International Journal of Food Science & Technology》2022,57(3):1573-1586
Thermal action in extraction process had effects on characteristic tryptic peptides identification and gelling properties of porcine gelatin. SDS-PAGE, HPLC-LTQ/Orbitrap high-resolution mass spectrometry, texture analyser and rheometer were used to evaluate collagen depolymerisation degree, characteristic tryptic peptides and gelling properties of gelatins prepared in various thermal actions. Results showed that with increasing temperature and time, depolymerisation degree enlarged, while gel strength, gelling and melting temperature decreased. Mass spectra showed that 47 and 49 common characteristic tryptic peptides were identified in gelatins extracted at 50 °C and 100 °C with various times, respectively. Moreover, 34 common characteristic tryptic peptides were identified in all gelatin samples. Further comparison between this work and our previous investigations yielded 20 common characteristic tryptic peptides, which stably exist in various thermal actions. These common characteristic tryptic peptides may be very helpful for the accurate authentication of porcine gelatin. 相似文献
2.
4.
Scientometrics - Examining the relationships among scientific disciplines is important today, but existing methods are limited by the contents and structure of their bibliographic databases. We... 相似文献
5.
Sha Liu JianHui Xiao YaPing Feng MianLing Zhang Ying Li Jin Tu LiYa Niu 《International Journal of Food Science & Technology》2022,57(3):1791-1803
Konjac glucomannan/sodium alginate composite edible boba (KGM/SA-boba) with good taste is very popular in China, and it is an outstanding carrier for health potential ingredients. In this work, KGM/SA-boba were fortified with 0.25, 0.50, 0.75 and 1.00% purple sweet potato anthocyanin (PSPA), then characterised by the water distribution, texture, microstructure, in vitro release property of PSPA and antioxidant capacity. LF-NMR analysis demonstrated that the free water of KGM/SA-boba could transfer to tightly bound water with the addition of PSPA that made it with better water-binding ability, higher springiness and lower hardness. And the results of SEM and rheology showed that PSPA could stabilise the microstructure of KGM/SA-boba by forming more amorphous regions and hydrogen bonds proved by the results of DSC and FT-IR. Furthermore, 50% of PSPA in PSPA-fortified KGM/SA-boba can be released at the first hour in a simulated gastrointestinal environment. And the scavenging capacity of DPPH and ABTS of the PSPA-fortified KGM/SA-boba after digestion was higher than that of PSPA alone. Generally, PSPA could improve the texture while KGM/SA-boba in turn would make PSPA more stable in the gastrointestinal digestive system. 相似文献
6.
Zhenzhen Huang Xinxi Yang Qiqi Chen Leqi Chen Siyue Liang Qingzhu Zeng Ruifen Zhang Fei Huang Lihong Dong Dongxiao Su 《International Journal of Food Science & Technology》2022,57(5):3060-3068
This study aims to fabricate mineral-loading nanocarriers using natural materials. The interaction patterns between ovalbumin (OVA) and four water-soluble polyphenols, namely ferulic acid (FA), (-)-Epigallo-catechin 3-gallate (EGCG), gallic acid (GA) and epicatechin (EC), were investigated. Results showed that the optimised conditions for preparing stable OVA–polyphenol complexes are at the OVA–polyphenol ratio of 4:1 at pH 6, under which OVA–FA and OVA–EGCG showed the highest stability and mineral-loading capacity among four OVA–polyphenol complexes. The fluorescence results indicated that the addition of EGCG and FA induced a significant fluorescence quenching to OVA. The interaction between OVA and polyphenols involved hydrogen bonding, hydrophobic interaction and electrostatic interaction. Fourier transform infrared spectroscopy (FTIR) analysis suggested that both FA and EGCG enhanced the stability and orderliness of the structure of OVA. The transmission electron microscopy images also exhibited the spherical structure of OVA after the addition of FA and EGCG. Furthermore, scanning electron microscope–energy dispersive X-ray spectrum results suggested that OVA–FA and OVA–EGCG complexes were better mineral carriers than OVA–GA and OVA–EC. This study may serve as the theoretical support for the promising application of OVA in the fabrication of mineral-loading nanocarriers in functional food and pharmaceutic. 相似文献
8.
Jiahong Kang Jingxiao Liu Fei Shi Yutong Dong Shuwen Jiang 《Ceramics International》2021,47(11):15631-15638
In this paper, Zn-doped VO2 nanoparticles have been successfully fabricated by a two-step hydrothermal-annealing process, and the thermally induced visible light transmittance enhancement of Zn-doped VO2 has been studied for the first time. It is found that Zn-doped VO2 not only exhibits excellent solar modulation ability (ΔTsol = 15.27%) but also can reduce the phase transition temperature and increase the visible light transmittance after the heat-induced phase transition (ΔTlum=+5.78%). Moreover, with the increase of Zn doping concentration, the phase transition temperature (Tc) and phase transition hysteresis (ΔT) both decrease. It is shown that the Zn-doped VO2-PU films not only have good solar light modulation ability and properties of improving visible light transmission after phase transition, but also have good durability. The research result is of great significance for improving the visible light transmittance after phase transition and realizing the practical application of VO2 in the field of smart windows. 相似文献
9.
Dr. Jie Zang Dr. Fei Ye Dr. Sara M. Ø. Solbak Dr. Lars J. Høj Prof. Mingjie Zhang Prof. Anders Bach 《ChemMedChem》2021,16(6):949-954
Inhibition of PSD-95 has emerged as a promising strategy for the treatment of ischemic stroke, as shown with peptide-based compounds that target the PDZ domains of PSD-95. In contrast, developing potent and drug-like small molecules against the PSD-95 PDZ domains has so far been unsuccessful. Here, we explore the druggability of the PSD-95 PDZ1-2 domain and use fragment screening to investigate if this protein is prone to binding small molecules. We screened 2500 fragments by fluorescence polarization (FP) and validated the hits by surface plasmon resonance (SPR), including an inhibition counter-test, and found four promising fragments. Three ligand efficient fragments were shown by 1H,15N HSQC NMR to bind in the small hydrophobic P0 pockets of PDZ1-2, and one of them underwent structure-activity relationship (SAR) studies. Overall, we demonstrate that fragment screening can successfully be applied to PDZ1-2 of PSD-95 and disclose novel fragments that can serve as starting points for optimization towards small-molecule PDZ domain inhibitors. 相似文献
10.
Nianxiu Duan Junjun Li Sha Song Feng Wang Yiwei Yang Di Nie Caifen Wang Yingjie Sheng Yali Tao Jie Gao Can Xu Yan Wei Yong Gan 《Advanced functional materials》2021,31(46):2100605
Tumor-specific enhanced delivery of chemotherapeutics and modulators to tumor cells and activated pancreatic stellate cells (aPSCs), respectively, represents safer and more effective therapy for pancreatic cancer. Herein, a membrane type 1-matrix metalloproteinase (MT1-MMP)-cleavable spacer is used to assemble low-density cRGDfK onto thermosensitive liposomes loaded with phosphorylated calcipotriol (PCAL) and doxorubicin (DOX), yielding MR-T-PD. The liposome-linked cRGDfK prodrug on MR-T-PD surface is first activated by MT1-MMP, which is selectively expressed on tumor endothelial cells, to release cRGDfK. The free cRGDfK specifically promotes tumor angiogenesis, leading to 3.4-fold higher accumulation and a wider distribution of MR-T-PD in tumors. Furthermore, MR-T-PD rapidly releases PCAL and DOX into the interstitium under heat treatment. The released DOX enters tumor cells to induce apoptosis, whereas the PCAL prodrug is converted to CAL by alkaline phosphatase on the surface of aPSCs; CAL can then enter aPSCs to induce quiescence and promote the antitumor effect of DOX. Finally, by enhancing the exposure of DOX and CAL to tumor cells and aPSCs, respectively, in a tumor-specific manner, MR-T-PD exerts superior efficacy (a 5.9-fold decrease in tumor weight) without causing additional side effects. Overall, this prodrug-based smart liposome system represents a promising paradigm for pancreatic cancer therapy. 相似文献